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Central alpha-agonists (e.g. clonidine (Catapress)) are very effective, but I don't usually recommend them because of prominent side effects such as fatigue.
While I still had some doubts, I continued to be impressed by the 10percentt advantage in remission rates that Effexor held over S.S.R.I.'s; that advantage seemed significant enough to overcome Effexor's more prominent side effects.
Urinary incontinence and erectile dysfunction are the most prominent side effects of radical prostatectomy [ 6].
The prominent side effects are alopecia and cystitis, which are caused by another metabolite acrolein.
The administration of docetaxel is associated with prominent side effects such as neutropenia, alopecia, leucocytopenia and nail changes (BC Cancer Agency, 2003; British National Formulary, 2003).
A more stable analogue of prostacyclin, treprostinil, can also be given intravenously but is associated with more prominent side effects, headaches and leg pain.
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Cyclosporine A (CsA) is used as an immunosuppressive agent, and its prominent side effect is the induction of gingival overgrowth.
A prominent side effect of TMZ is induction of profound lymphopenia, which some suggest may be incompatible with immunotherapy.
This phenomenon was termed as "the paradox of indomethacin", whose most prominent side effect and reason for discontinuation (headache) is the very symptom for which it provides a remarkable therapeutic efficacy [31].
However, accumulated evidence shows that the therapeutic efficacy of L-DOPA is gradually lost over time, and abnormal involuntary movements, dyskinesias, gradually emerge as a prominent side effect of the previously beneficial doses of the drug [5] [7].
Neuropathy has been a prominent side effect in previous phase II and phase III trials with a frequency of grade 3 neuropathy in the 5 20% range [14], [15], [16], [22], [23], [24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com