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Cyclosporine A (CsA) is used as an immunosuppressive agent, and its prominent side effect is the induction of gingival overgrowth.
This phenomenon was termed as "the paradox of indomethacin", whose most prominent side effect and reason for discontinuation (headache) is the very symptom for which it provides a remarkable therapeutic efficacy [31].
However, accumulated evidence shows that the therapeutic efficacy of L-DOPA is gradually lost over time, and abnormal involuntary movements, dyskinesias, gradually emerge as a prominent side effect of the previously beneficial doses of the drug [5] [7].
Neuropathy has been a prominent side effect in previous phase II and phase III trials with a frequency of grade 3 neuropathy in the 5 20% range [14], [15], [16], [22], [23], [24].
The most prominent side effect due to fotemustine was thrombocytopenia which occurred in 16 patients but never exceeded grade 3 nor needed thrombocyte substitution (Table 2-wrap>).
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Central alpha-agonists (e.g. clonidine (Catapress)) are very effective, but I don't usually recommend them because of prominent side effects such as fatigue.
Urinary incontinence and erectile dysfunction are the most prominent side effects of radical prostatectomy [ 6].
The prominent side effects are alopecia and cystitis, which are caused by another metabolite acrolein.
The administration of docetaxel is associated with prominent side effects such as neutropenia, alopecia, leucocytopenia and nail changes (BC Cancer Agency, 2003; British National Formulary, 2003).
A more stable analogue of prostacyclin, treprostinil, can also be given intravenously but is associated with more prominent side effects, headaches and leg pain.
Second-line bacteriostatics, such as p-aminosalicylic acid, ethionamide and cycloserine have established clinical efficacy but have more prominent side effects [ 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com