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One of the most prominent phenotypes of both elg1 mutants and ctf4 mutants is their increased levels of recombination.
Surprisingly, after the first brain CK knockout transgenic mice became available, it took almost 10 years to figure out some of the most prominent phenotypes of this type of transgenic mice.
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To exclude cardiac malfunction, the most prominent phenotype of Atgl−/− mice [12], Schoiswohl et al.
Warburg's effect is a prominent phenotype of HLRCC tumors [36].
The most prominent phenotype of foscrb Y10A embryos is the over-contraction of AS cells, most likely mediated by DPak.
Despite the near-ubiquitous LMNA expression in most somatic cells, DCM is the most prominent phenotype of the R225X mutation.
It should be noted that the prominent phenotype of Neat1 KO mice was observed only in the ovary, an organ that expresses extremely high levels of Neat1_2.
In line with this scenario, the prominent phenotype of our case might result from the combination of HDAC4 haploinsufficiency with 1p36 duplication and/or other genetic factors that remain to be uncovered.
In addition, the most prominent phenotype of SMARCA2 null mice is a larger (about 14% more than normal) body size with a disproportionately increased bone and muscle mass [ 74].
The direct mitogenic stimulation of endothelial cells as prominent phenotype of B. henselae infection turned out to be independent of the VirB/VirD4 system and was even found to be counterbalanced by VirB/VirD4-dependent cytostatic effects observed at high infection doses (Schmid et al., 2004).
Furthermore, the decreased EJP decay times recorded in Akt1 /and1 and muscle-directed Akt1 RNAi animals also mimicked a prominent phenotype of Gtaxin mutant animals (Gorczyca et al., 2007), supporting the hypothesis that changes in SSR and muscle membranous system were the reason for these physiological changes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com