In context of an immune response to bacterial infection, the Th1 response signaling was the only prominent pathway that appeared in our analysis.
FGF signalling is a prominent pathway that controls epithelial cell proliferation during embryonic development.
Among such enriched pathways we found several prominent signaling pathways that have been implicated in tumor biology.
Thus there are several prominent signalling pathways that stimulate mitochondrial biogenesis and energy metabolism, while simultaneously regulating neuroplasticity.
Cytosolic calcium levels are tightly controlled and their modulation is part of most prominent cellular signalling pathways that regulate many cellular processes (Berridge et al., 1998, 2000).
TOR and PKA are two prominent, evolutionarily conserved signal transduction pathways that couple nitrogen and carbon source availability, respectively, to regulate diverse cell responses that ultimately drive cell growth and proliferation and inhibit sexual differentiation.
We assessed evidence for an excess of association signals within the genes of three neurobiological pathways that are prominent in prior literature on reading and language: axon guidance, neuronal migration and steroid sex hormone biology (see Discussion for the relevant citations).
While we observed that many observed driver genes were included in prominent signaling and regulation pathways we determined pathways that were enriched with such genes.
Furthermore, we were able to identify groups of genes that are known or likely to play a role in cnidarian-dinoflagellate symbioses, including oxidative stress pathways that emerged as a prominent biological feature of this transcriptome.
ErbB tyrosine kinases, the most prominent among them being epidermal growth factor receptor (EGFR), when phosphorylated activates signal transduction pathways that enhance cell survival, motility, and proliferation.
