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However, the most prominent pathways are related to oxidative stress, mitochondrial electron transport chain, vacuolar acidification, regulation of macroautophagy associated with protein target to vacuole, cellular response to starvation, and negative regulation of transcription from RNA polymerase II promoter.
Given the extreme genomic instability which is notorious in osteosarcoma and has led to the formulation of a novel genetic mechanism, chromothripsis [ 32], it is not surprising that the most prominent pathways are associated with this signature.
Although a few prominent pathways are well studied, our knowledge of majority of biological pathways (including the limited number of pathways documented in various pathway databases) remains largely fragmented.
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During the multifactorial process of systemic inflammation, one of the prominent pathways is the activation of immune cells and endothelial cells by lipopolysaccharide, a structural component on the outer membrane of gram-negative bacteria [ 3].
As a number of prominent cellular pathways are critical to the survival of both tumor cells and heart cells, it comes as little surprise that therapies targeting those pathways have consequences in both tissues.
Since the most prominent neuronal pathways are those that interconnect components of functional circuits, our analysis validates the intrinsic connection between network structure and the functions of the nervous system.
RNAi can be essential for antiviral defense in plants and lower eukaryotes (reviewed in [1]); however, in higher eukaryotes, innate immune mechanisms such as those mediated through interferons and Toll-like receptor pathways are prominent, leading to questions regarding the antiviral role of RNAi in these organisms.
The vernalization pathways are a prominent example, with FLC encoding the main repressor of flowering in Arabidopsis and VRN2 in cereals.
CA1-PNs receive multiple glutamatergic inputs, of which the SC and TA pathways are particularly prominent.
These coherently restricted diffusion pathways are most prominent in axonal bundles.
Brain structures such as the OSVZ, the IFL, ocular dominance columns (ODCs) and the parallel visual pathways (i.e. the magnocellular, parvocellular and koniocellular pathways) are especially prominent in higher mammals including ferrets.
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