Consistent microscopic features include prominent pathology at the brain surface overlying the polymicrogyric cortex.
In this series, MCD was the prominent pathology in the extra-TLE group, and their pathoneurophysiology will be different to that of hippocampal sclerosis, for example.
We found hippocampal sclerosis to be the prevalent pathology in the TLE group (5 of 9 patients), while malformations of cortical development (MCD) were the prominent pathology in the extra-TLE group (5 of the 10 patients, Table I).
While the correlation of modules in the cerebellum and frontal cortex BA4 networks was largely comparable, the correlation of the caudate nucleus modules was higher, highlighting the prominent pathology in the striatum of HD patients (compare Figure 1B, D and F).
PTS are prominent secondary pathologies [6] that can cause excessive release of excitatory neurotransmitters, alterations in blood pressure, decreased oxygen delivery, elevations in intracranial pressure, and an increase in neuronal death following TBI.
The rabbits with the most prominent lung pathology showed the greatest detectable δ13CO2 signal.
Rather, it simply indicates that they share FUS accumulation as the most prominent molecular pathology.
The metabolic deficits are found in areas disconnected from the prominent subcortical pathology of PSP.
Further still, there are reports of severe involvement of the substantia nigra without any prominent DMV pathology [ 56, 57].
We then hypothesized that axons might be disrupted either as a cause or a consequence of this prominent myelin pathology.
