Sentence examples for prominent pathological feature from inspiring English sources
Intriguingly, although NPC proteins are ubiquitously distributed in the body and regulate intracellular cholesterol trafficking [1], the most prominent pathological feature of the disease is progressive neuronal death, particularly of neurons in cerebellum, cortex, thalamus and brainstem [reviewed in [2]].
Another prominent pathological feature of this neuronal population in our PS1xAPP mice is the extensive development of axonal dystrophies associated to Abeta plaques [ 15].
Next to α-synuclein deposition, microglial activation is a prominent pathological feature in the substantia nigra (SN) of Parkinson's disease (PD) patients.
While their spatiotemporal development parallels the appearance of non-motor and motor symptoms [ 10], little is known about changes in microglial activation, another prominent pathological feature of PD [ 11– 13].
In BRI2-related dementia [ 13], ABri amyloid is not produced by vascular smooth muscle cells, yet CAA is a very prominent pathological feature; this again suggests that amyloid in CAA is derived from the central nervous system.
Gliosis is a fundamental response of the central nervous system to scrapie infection in sheep [ 40], and the current and previous findings [ 16, 43, 45] demonstrate that it is a prominent pathological feature of the retinopathy in affected animals.
Synaptic loss and dysfunction are the most prominent pathological features of AD and these processes best correlate with the development of AD-related cognitive decline.
Collectively, these results suggest that the M1-type MYPS cell associated molecules galectin-3 and MIF both promote the most prominent pathological features of experimental trypanosome infections (anemia and liver injury).
Microhaemorrhages are a well-known pathological feature of schwannomas.
The most prominent pathological finding was the appearance of significant death of Schwann cells with apoptotic morphology.
Lewy bodies are a key pathological feature of PD.
