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These include: a strong and precise (point-to-point) projection from lamina 4B to lamina 2/3A, a reciprocal projection from 2/3A back to 4B, a definite projection from lamina 4B to 5B, as well as a prominent input to lamina 6 from 5B.
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As we discussed above, the most prominent inputs to the 'canonical' dopamine neurons are from the nucleus accumbens, a part of the ventral striatum, though TS-projecting dopamine neurons received far fewer inputs from the nucleus accumbens.
Although we were able to rule out some of the areas mentioned above which preferentially project to TS-projecting dopamine neurons, many brain areas still remain on the list of prominent inputs to VS-projecting dopamine neurons.
Prominent input areas appear to be located around the DM/VM tracts, and in the terminal plexus of a9.
A summary of the distribution of inputs among the 20 most prominent regions providing input to dopamine neurons.
The amygdala also receives prominent input from the insula and from the hippocampus and rhinal (olfactory) cortices.
There was a prominent input from the wake active areas such as the ventromedial hypothalamus (VMH), posterior lateral hypothalamus (pLH), lateral hypothalamus (LH), tuberomammillary nucleus (TMN) and lateral pontine tegmentum (LPT).
The largest and the most central of LMCs, L1 and L2, share their synapses, whereas synaptic input to more proximal L3 cells is less prominent [35].
The 20 most prominent inputs are compared in Figure 4 figure supplement 1. DOI: http://dx.doi.org/10.7554/eLife.10032.012 10.7554/eLiFigure32.013 Figure 4 figure supplement 1.
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