Sentence examples for prominent effector of from inspiring English sources
ROCK1 is a prominent effector of RhoA that regulates the acto-myosin machinery and other signaling pathways [29].
Stat3 is a prominent effector of the non-receptor tyrosine kinase Src [ 24].
Although the mechanisms coupling TORC1 to Tap42 PPase complexes remain to be elucidated, genetic arguments clearly position Tap42 as a prominent effector of TORC1.
According to this analysis, the most prominent effectors of the NaCl stress response are genes involved in detoxification, transport, protein turnover, energy metabolism, and production of osmoprotectants.
In RA, neutrophils are localized mainly to the SF, but not to the synovial membrane, and act as prominent effectors of inflammation and cartilage damage by releasing various enzymes [ 32].
However, the fact that the most prominent effector mechanisms involved in the antiviral defence are controlled by type I IFNs, in particular IFN-β, indicates that the expression of many genes classified as Th1 inducing may likewise be controlled by IFN-β [14], [36].
Ultraviolet light appears then to be a most prominent effector agent.
These findings further emphasize on the role of KRAS/PAK1/Crk axis as a prominent downstream effector of KRAS in NSCLC.
Prominent effectors in peroxisome biogenesis identified in that study include actin-regulating proteins, which function through the action of Rho regulators (e.g., Rho1), as well as proteins involved in phosphatidylinositol metabolism (e.g., Vps34).
The most prominent downstream effectors of mTORC1 include ribosomal S6 kinase (S6K) and the eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) which regulate the translation of ribosomal and cap-dependent proteins essential for cell growth and G1 to S cell cycle progression [ 24, 25].
Active Ras will then proceed to stimulate a number of effectors, including the prominent classical effectors phosphoinositide-3 kinase (PI-3K) and Raf; Ral-GDS and Tiam-1, exchange factors leading to the activation of small GTPases Ral and Rac; and several other less well-defined effectors.
