MALDI imaging and CE-MS were also performed for other nucleotides namely guanosine and uridine nucleotides and revealed that among all 3 nucleotides, adenosine nucleotide exhibits the most characteristic and prominent cellular dynamics (Fig. S1).
While elucidation of the precise actions of PINK1 has to await the identification of PINK1-phosphorylation substrates, in Pink1−/− brain the bioenergetic deficit is clearly more prominent than mitochondrial dynamics failure.
In addition to eliciting prominent short-term dynamics, the delivery of place-field associated spike trains on a longer timescale led to robust potentiation of mossy fiber synaptic responses.
A prominent feature of such dynamics is that, unlike other neural adaptation mechanisms (see [22], [23]), adaptive threshold dynamics allows a neuron to raise its firing threshold without the generation of previous APs.
Adler assigned a prominent place to family dynamics in personality development.
But during the substorm growth phase, the magnetic time variations are prominent in the particle dynamics.
This improvement is particularly important for computations in which an elastic boundary separates chambers containing fluid at substantially different pressures, a situation which is prominent in cardiac fluid dynamics during the contraction of the ventricles.
Gene expression analysis is, due to its prominent role in cellular dynamics, a critical component of network and systems biology [4].
The data reported herein suggest that mutant PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression and hence, deserve further exploration as therapeutic targets.
