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One prominent drawback of the classical EST, which is shared by other in vitro assays for embryotoxicity such as the whole embryo culture test and the rat limb bud micromass test, is its reliance on a morphological endpoint.
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Several of the most prominent drawbacks of high temperature concreting include the increased water demand, slump loss, drying shrinkage, autogenous shrinkage, decreased mechanical and durability properties.
A summary of the more prominent drawbacks in the legislation relevant to the registration requirements is given in the second column of Additional file 1.
However, these conventional methods have prominent drawbacks associated with extraction, sample preparation, intensive solvent usage, intensive labor, expensive devices, and time consumption.
Yet, both of them have prominent drawbacks.
This method has a high diagnostic accuracy of 95 to 99% (Dooley et al, 1984), but is plagued with some prominent drawbacks, which limit its suitability for population-based screening.
This drawback is more prominent for additive materials such as Stellite 1 which are by nature crack-sensitive during the hardfacing process.
Drawback: large file sizes.
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