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As shown, the integrated profiles show prominent cell cycle dependencies (period ≈ 85 minutes).
Among the alk en yl trisulfides, DATS, dibutenyl trisulfide and dipentenyl trisulfide, all unsaturated sulfide compounds, caused marked disruption of microtubules and prominent cell cycle arrest during the mitotic phase; whereas the saturated sulfide compounds showed very little effect.
To explore the mechanism responsible for the difference in Rb phosphorylation and G1-to-S transition, we compared the two groups of cells in their expression of some of the most prominent cell cycle regulatory proteins.
Activation of MYC in the SBK resulted in a less prominent cell cycle response compared to β-cells, with a change in expression of 144 cell cycle- and proliferation-related transcripts within 8 hours of MYC activation - 73 genes up-regulated and 74 genes down-regulated (Additional file 1, Table S2).
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Further mechanistic evaluations indicated that 11l treatment in MCF-7 cells induced accumulated DNA double-strand breaks, prompted remarkable apoptosis, and caused prominent G0/G1 cell cycle arrest.
Functional categorization as identified using Gene/Gene Set overlap matrix with 17 TFs identified as biomarkers for full set of OC genes (additional file 8) showed overlap which were prominent for cell cycle associated TFs based on data from E2F1, E2F3-4 and TFDP-1 genes.
Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence.
Cdc25B and cdc25A phosphates are prominent stimulators of cell cycle progression and recent studies have also suggested their oncogenic roles.
The more prominent changes in cell cycle controlling proteins found for Hyper-IL-6-treated Colon26 cells would account for the enhanced suppression of proliferation and clonogenicity.
The prominent regulation of cell cycle genes of the miR-US25-1 attracts us to explore its role in the atherosclerosis promotion.
The prominent regulation on cell cycle genes of the miR-US25-1 attracts us to explore its role in the atherosclerosis promotion.
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