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I believe that we must have the conscience – I would even say the courage – to stop a treatment that no longer makes sense, that can provide no further benefit to the patient (principle of beneficience), that may cause discomfort or even pain (maleficience), and that prolongs the use of limited resources (distributive justice).
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There are some potential antibiotics to treat gonorrhoea on the horizon, but, said Hughes, "We really need to prolong the use of the existing drugs we have and ensure we have good stewardship of the antibiotics we have and we are not treating people with drugs where there are high levels of resistance".
But just think what we will accomplish once our civilization commits all of its genius to making this transformation happen and stops working overtime to prolong the use of fossil fuels.
Our results confirm that the strategy of prolonging the use of bevacizumab until progression is tolerable and often associated with encouraging long-term clinical outcomes.
It is arguable that the guidelines might currently prolong the use of central catheters that are associated with higher morbidity and mortality as well as increased cost to health services.
In the absence of international guidelines, common current practice for the treatment of HR+ advanced breast cancer in many countries, including the United Kingdom, consists of sequential administration of hormonal therapies, prolonging the use of endocrine therapy while the disease status allows before switching to more toxic chemotherapies.
Understanding what scenarios are likely to promote its development will be crucial to prolong the use of microbial control agents; frequent applications, constrained gene flow, reduced pathogen variation, gene × environment interactions, and the genetic basis of resistance all appear to be contributing factors to the evolution of resistance.
This procedure of designing the sensor chip improved efficient use of the ligands and could prolong the analytical use.
Improvements in pMDI design and reformulation with propellants such as hydrofluoroalkanes may offer significant advantages over CFC-pMDIs and prolong the widespread use of pressurised drug delivery systems for many years to come.
Computer navigation equipment is expensive, and its use prolongs the operation time [ 7].
However, even with reduced data uploading time, this scheme adversely prolongs the tour length, especially when using only one SenCar.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com