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Nowadays, the disease can be efficiently managed with a rigorous diet and adjuvant drug therapy, prolonging long-term survival.
Currently available chemotherapic agents and conventional radiotherapy are not effective in prolonging long-term survival of CCA patients.
By using pictures taken by using magnifying NBI, fine mucosal structures of the 95 lesions were classified into following four categories: small round (uniformly arranged small round pits), prolonged (long holed or oval shaped pits), villous or ridge (villous or ridge like structures, pit is not seen), and unclear (structures is not observed) patterns.
However, aggressive cytoreductive surgery (CRS) followed by intraperitoneal chemotherapy (IPC), may produce prolonged long-term survival and even cure [ 1- 5].
It is worth noting that a similar model-dependent effect of PARP inhibitors was observed between short-term versus prolonged long-term in vitro assays [ 24].
There is ample evidence for the latter, since during prolonged long-day exposure and in non-seasonal animals, leptin resistance is positively correlated with body fat content (Friedman and Halaas, 1998).
We recently showed that digestion of PNNs in the perirhinal cortex (PRh), a structure critical for object recognition (OR) memory (Bartko et al., 2007; Mumby and Pinel, 1994; Winters et al., 2004), greatly prolonged long-term OR memory in wild type (WT) mice, and an identical memory prolongation was seen in mice lacking CNS Crtl1/Hapln1, an essential component of PNNs (Romberg et al., 2013).
The aim of this study was to evaluate tools for improving LTBI diagnosis by analyzing the IFN-γ response to RD1 proteins in prolonged (long-term response) whole blood tests in those subjects resulting negative to assays such as QuantiFERON-TB Gold In tube (QFT-IT).
And at the risk of prolonging a long chat, one last question for you, Ashley.
That's prolonging the Long Depression.
However, differences in eye tracking variables, such as the ratio of intra to extra lead saccades, suggest that checklist use modified what participants were doing, as well as prolonging how long they took to check.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com