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The longevity prolonging effect of the proteasome subunit overexpression was found to depend on the FOXO transcription factor DAF-16 and was associated with its elevated transcriptional activity.
Similarly, lifespan extension by CIN was also blocked in mutants of serotonin receptors (ser-1) and anti-oxidative enzyme (mev-1) (Fig. 1C&D, Table 5), suggesting that CIN requires the insulin signaling pathway, anti-oxidative pathway and serotonin signaling for its lifespan prolonging effect.
Strong doubts over the lifespan prolonging effect of Sir2 overexpression have recently been expressed [ 18].
Our study confirms the prolonging effect of invasive ventilation on ICU stay.
However, these diseases are also associated with an important morbidity component, due to the life prolonging effect of continuously improving medical practice [ 4].
BALB/c mice treated from the time of leukaemia infection, however, showed a life prolonging effect with polyanion dextran sulphate and also of neutral dextran.
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A more complex correlation between oxidative stress and longevity emerges if recent results regarding the life prolonging effects of mild stressors are taken into account.
Although the underlying mechanisms are only partially understood, it has been suggested that the endothelial glycocalyx may play an important role in the life prolonging effects of LMWH in patients.
Also, several studies indicate a health and lifespan prolonging effects of high proteasome activity.
Indeed a recent study found that SNPs in the NOS1AP gene modify the QT, prolonging effects of certain drugs [ 50].
Icariin represents an important active component in TFE and exhibits similar life prolonging effects of TFE in C. elegans [ 8] and mice.
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