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We made the prospective and arbitrary decision to categorise the closure time into 'normal' and "prolonged" values based on the 90th centile of the distribution for all patients enrolled in the study.
Utilising the normal and prolonged values of closure time, the sensitivity, specificity, negative and positive predictive values and likelihood ratio for identifying patients with non-cardiac symptoms were determined.
Sir, In their discussion Lyratzopoulos et al (2003) make the crucial point that they were not able to examine whether prolonged values of either the primary care interval or the number of pre-referral consultations were either justifiable or preventable.
Finally, we could not examine whether any of the prolonged values of either the primary care interval or the number of pre-referral consultations were either justifiable or preventable.
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Prolonged laboratory values were seen in 22.5% of PT and 17.4% of aPTT assays; 66.0% of abnormal PTs and 87.5% of abnormal aPTTs were repeated.
Consequently, T1620Kd channels are unlikely to contribute significantly to prolonged QTc values.
Prolonged APTT values have clinical relevance as an indicator of factor deficiency or the presence of coagulation inhibitors [4].
Prolonged T1 values have also been observed in ischaemic myocardium in humans and animals.
8, 10 Although liver involvement might be expected to contribute to derangements in hemostatic parameters, we only found prolonged PT values in the patients with liver failure.
With the exception of slightly more prolonged t1/2 values reported in the present combination study, NGR hTNF Pks were in reasonable agreement with those found in a low-dose, single-agent phase I study (Gallo-Stampino et al, 2007).
The benefit of this prolonged PAE value of tobramycin may allow for prolonged dose intervals without reduced efficacy and possibly a lower frequency of adverse events during K. pneumoniae therapy.
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