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Prolonged stimulus in the form of record-low interest rates and the money-creation process known as quantitative easing has been one factor.
Public debt will soar because of weak growth, prolonged stimulus spending and the growing costs of cleaning up the financial mess.
Furthermore, we show that prolonged stimulus durations and repetition times of 3 s still allow an effective suppression of speech-related artifacts in fluent as well as in nonfluent speakers.
Under prolonged stimulus, fluorescent intensity reached a maximum after 20 50 s and then began a recovery towards baseline levels.
Based on our results, Shal/Kv4 channels regulate the initiation of firing, enable neurons to continuously fire throughout a prolonged stimulus, and also influence firing frequency.
The exhaustion of cellular response after repeated or prolonged stimulus (Fig. 2a e, Fig. 4c) suggests that store depletion is occurring.
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Prolonged stimuli used in this study evoked bursts of firing similar to motoneuron activity seen during locomotion.
Together, our results suggest that Kv4 repolarizes the membrane during prolonged stimuli, and that this is critical for maintaining excitability during repetitive firing.
This was evident in the amount of current injection required to induce repetitive firing during both prolonged stimuli; wild-type neurons consistently required larger current injections to induce firing (Figure 3C D, 4A).
Prolonged stimuli activate transcription factors such as activator protein-1 through elevation of intracellular calcium and the subsequent activation of calcineurin.
Furthermore, using a pharmacological approach we determine that prolonged wound stimulus results in permanent activation of the TGFβ pathway that is independent of further wound stimulus.
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