Endpoints such as DFS or PFS may underestimate the activity of novel therapies if associated with prolonged stable disease or unconventional responses, even though these responses may translate into a prolonged survival benefit [ 39, 40].
Foss, F. et al. Romidepsin for the treatment of relapsed/refractory peripheral T cell lymphoma: prolonged stable disease provides clinical benefits for patients in the pivotal trial.
Prolonged stable disease was observed, suggesting ramucirumab efficacy in various solid tumors.NCT00786383.
Addition of axitinib delivered greater benefits than expected in the number of patients achieving prolonged stable disease with a moderate increase in AEs.
Clinical activity was observed in heavily pretreated patients with ErbB1-expressing and/or ErbB2-overexpressing metastatic cancers, including four PRs in patients with trastuzumab-resistant breast cancers and prolonged stable disease in 10 patients.
One patient treated at dose level 1 had a partial response and five other patients treated at the recommended phase II dose had prolonged stable disease for more than 1 year.
In addition, several unique characteristics of immunotherapies, including (1) appearance of new lesions, (2) delay in onset of clinical responses, (3) increase of tumor volume before tumor shrinkage, and (4) prolonged stable disease, can be detected by irRC (Wolchok et al., 2009; Hoos et al., 2010).
Finally, the reaction tubes display only a uniform ramping to the target temperature followed by a prolonged stable isothermal phase.
Some epithelial mesothelioma patients may have prolonged stable disease for months or even years without chemotherapy.
A subset of patients experienced prolonged stable disease independent of dose level.
Biologic responses were often associated with partial responses and prolonged stable disease.
