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The use of CD19L sTRAIL higher dose levels and prolonged schedules may cause unexpected side effects alone and/or in combination with low dose TBI in clinical settings.
This is in accordance with the results of a phase I study with prolonged schedules of irinotecan, where no cholinergic syndrome was observed.
These results suggest that there may be thresholds with regard to temozolomide dose levels, treatment periods, and pharmacologic exposure, above which further AGAT inactivation does not occur and with low dose administered for prolonged schedules this threshold is exceeded with temozolomide.
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Etoposide phosphate infusions allow prolonged scheduling of etoposide with pharmacokinetic monitoring to allow dose adjustments.
A correlation between AGAT activity in PBMC and haematological toxicity has been demonstrated by Tolcher et al (2003) in patients treated with a prolonged schedule.
Such an immunostimulatory activity was observed only when rapamycin was administered in a high-dose short therapeutic course, as opposed to both a single, low-dose course as well as prolonged treatment schedules [ 88, 89].
As accelerated tumour repopulation is a major cause of radiotherapy failure, especially when prolonged radiotherapy schedules are applied, it may be suggested that tumours containing a large compartment of CSCs that can enter a rapid proliferation phase during the radiotherapy course could benefit from short radiotherapy schedules (Geara et al, 1991).
The Pareto frontier includes solutions ranging from expedited, energy intensive schedules to prolonged, energy efficient schedules.
To overcome these difficulties, clinicians have attempted to prolong infusion schedules or use corticosteroids and anti-histaminic drugs as a part of a pre-medication regimen.
Mrs. Merkel prolonged the plants' scheduled lifespan by an average of 12 years.
There were renewed calls yesterday from senior politicians, including the Mayor of London Boris Johnson, for the exhibition to be prolonged beyond its scheduled dismantlement on 12 November.
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