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A correlation between AGAT activity in PBMC and haematological toxicity has been demonstrated by Tolcher et al (2003) in patients treated with a prolonged schedule.
Our systematic review suggests that RT prolongs PFS and can be considered an option for patients who cannot tolerate a high dose or prolonged schedule of chemotherapy.
A prolonged schedule of dexamethasone might be better in preventing a pain flare.
17– 20 Second, a prolonged schedule of anticonvulsant weaning is typically required following successful lesion excision to maintain seizure freedom.
It must be considered an option for patients who cannot tolerate a high dose or prolonged schedule of chemotherapy.
Each topotecan treatment cycle is composed of 5 days of administration and even more prolonged schedule has been considered (Hochster et al, 1999).
Similar(50)
Etoposide phosphate infusions allow prolonged scheduling of etoposide with pharmacokinetic monitoring to allow dose adjustments.
Such an immunostimulatory activity was observed only when rapamycin was administered in a high-dose short therapeutic course, as opposed to both a single, low-dose course as well as prolonged treatment schedules [ 88, 89].
As accelerated tumour repopulation is a major cause of radiotherapy failure, especially when prolonged radiotherapy schedules are applied, it may be suggested that tumours containing a large compartment of CSCs that can enter a rapid proliferation phase during the radiotherapy course could benefit from short radiotherapy schedules (Geara et al, 1991).
The Pareto frontier includes solutions ranging from expedited, energy intensive schedules to prolonged, energy efficient schedules.
To overcome these difficulties, clinicians have attempted to prolong infusion schedules or use corticosteroids and anti-histaminic drugs as a part of a pre-medication regimen.
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