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In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface.
Therefore, this thiolated polymer is a promising carrier for progesterone providing a prolonged residence time and a controlled drug release.
The positive charge of the coating formulation ensured mucoadhesiveness to the particles and also prolonged residence time in the nasal cavity.
Therefore these thiolated polymers are promising delivery systems for nystatin providing a prolonged residence time and a sustained drug release in vitro under physiological relevant conditions.
The combination of both effects – mucus-permeating and mucoadhesive properties – might be a promising strategy for the development of oral drug delivery systems to overcome the mucus barrier and providing a prolonged residence time close to the absorption membrane.
The shale oil yield decreases with increasing particle bed thickness due to the increased shale oil cracking over shale ash in the prolonged residence time of volatile products inside the particle bed.
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Packing breakthrough curves were recorded at an array of prolonged residence times.
In vitro release studies proved the sustained release of TFB from TFB-NPs and TFB-SLNs in comparison with pure drug, indicating prolonged residence times of drug at targeting site.
The water molecules observed in the crystal structures of Gal3C are weakly bound at room temperature and have only slightly prolonged residence times relative to water molecules in the hydration layer surrounding the protein.
This reduces CNT agglomeration, prolongs residence time in the water column, increases CNT mobility and thus intensifies risk of exposure and toxicity [52 57].
Principal methods for reducing systemic activity include reducing the bioavailability of the ICS from the gastrointestinal tract and prolonging residence time of the ICS in the lung tissue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com