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Nevertheless, the recorded long-term transgen expressions are promissing for gene therapeutic approaches of degenerative IVDs, which usually need prolonged regeneration time (weeks to monthes).
It could be concluded, therefore, that these biomaterials are interesting for use as a medical device, principally in tissue with prolonged regeneration time and which require good mechanical properties.
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Understanding the molecular mechanisms responsible for such age-related changes in normal fate and function of adult stem cell populations is important if we ever aim to deter tissue degeneration, prolong regeneration, and improve healthy aging.
Th1, Th2, and Th17 conditioned medium, to varying extents, enhanced muscle precursor cell proliferation and inhibited their differentiation in vitro, and prolonged early stages of muscle regeneration in vivo.
The purpose of this study was to test the hypothesis that prolonged treatment with NAC impairs liver regeneration in ALI induced by APAP.
This adaptive mechanism may explain the link between LPR and laryngeal neuropathy because if sensory deficits are prolonged in time, aberrant sensory repair regeneration or central changes may develop.
After PH, severe hepatocyte necrosis, prolonged cholestasis, exacerbated inflammatory response, and delayed regeneration were observed in Tgr5-KO mice.
Athletes present with the key symptoms of prolonged underperformance and/or reduced trainability or disturbed regeneration following a period of heavy training load.
The authors conclude that despite the well-established beneficial effect of early and anti-inflammatory and antioxidant therapy after acetaminophen intoxication, prolonged treatment is likely to impair hepatocyte regeneration.
In agreement with a prolonged evolution of a M2a repair and regeneration phenotype, key M2 markers were maximal following only 4 h of stimulation and soluble factors from this early response had the greatest neuroprotective effect.
The prolonged degradation time of matrix barrier seems to provide prolonged protecting of the underlying graft supporting the bone regeneration process.
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