Since most people work for nearly two thirds of their lifetime, they have many, and often prolonged, opportunities for contacts with occupational carcinogens, resulting in the accumulation of exposure over a lifetime.
Due to slower elimination of cell-free particles, the model predicted that the number of ulcers containing cell-free particles often exceeded that of ulcers populated by HSV-infected cells, thus prolonging the opportunity for secondary seeding (Video 3).
The optimal timing for the use of these agents remains uncertain, however, it is likely that some approaches may be more suited to prophylaxis, while others may prolong the opportunity for eradication of early infection or may enable a treatment strategy for chronic infection.
Females on the contrary may benefit from multiple paternity [ 21, 22] and may therefore aim at prolonged fertilization opportunities for their eggs.
Consequently, catalytically impaired SHP2 mutants could display gain-of-function properties because of their ability to localize to the vicinity of substrates for longer periods of time, thereby affording the opportunity for prolonged substrate turnover and sustained RAS-ERK1/2 activation.
When interpreting such findings, it is important to remember that the initial neonatal stay, particularly in very preterm babies, may be prolonged, thereby reducing the opportunity for readmission during the first months of life.
Behaviorally, prolonged sitting displaces opportunities for engagement in light-intensity incidental activities that can lead to a reduction in whole-body energy expenditure (17).
The liver often maintains some regenerative capacity, so the rationale for supportive therapy and extracorporeal systems is to provide an environment facilitating recovery to create or prolong a window of opportunity for liver transplantation or, in the best-case scenario, until native liver recovery occurs in ALF or a period of stability for those with AoCLF [ 3].
Keeping an arrest quiet for days or weeks prolongs this opportunity.
In the Late Feeding scenario, we account for both the prolonged fast and for missed feeding opportunities by assuming high energy intake during June and July, similar to intake rates in the High Arctic35.
