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Freeman and colleagues reported a significant rise in mean blood cholesterol to over 250 mg/dl following prolonged intake a of ketogenic diet [ 86].
In rats prolonged intake of EtOH resulted in a neurotoxic effect on the basal forebrain cholinergic projection system (Floyd et al., 1997) and leads to a partial cholinergic denervation of the cortex, hippocampus and amygdala (Arendt et al., 1988).
These abnormalities may be attributed to prolonged intake of AEDs especially enzyme inducers.
For example, excessive doses of vitamin D due to overzealous fortification in milk resulted in hypercalemia; similarly, excessive and prolonged intake of vitamin A can lead to osteoporosis and hepatotoxicity [6 9].
Generally, the higher TDS causes gastro-intestinal irritation to the human beings and the prolonged intake of water with the higher TDS can also cause kidney stones and heart diseases (Garg et al. 2009).
Statistically, the intake of tortilla caused a change in plasma TEAC, which is in agreement with previous reports [23], although some others have not found changes in plasma antioxidant activity after prolonged intake of foods with high content of phenolic compounds [24].
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With prolonged chronic intake, absorption of Po through the digestive tract may increase sharply (Moroz and Parfenov 1972), possibly because of damage to the intestinal wall through persistent bombardment by alpha particles.
In veal calves older than 4 mo, prolonged high intakes of MR may lead to problems with glucose homeostasis and insulin sensitivity, ultimately resulting in sustained insulin resistance, hepatic steatosis, and impaired animal performance.
Erythrocyte non-protein thiol levels were significantly increased after 2 months of 30 ppm (PhSe 2 intake and then return to control levels after prolonged periods of intake.
However, whether prolonged chewing influences intake at a subsequent eating occasion is unknown.
Although no other severe complications were observed in either group, a prolonged poor oral intake was observed in five patients of group L. The principal factor related to a delayed discharge was slow progress with walk rehabilitation independently due to pain at the operated site and/or muscle weakness [8 10].
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