In rare instances prolonged use of anticancer drugs can lead to the development of secondary cancers.
However, in some instances, prolonged or severe exposure leads to a fatal outcome or permanent sequelae [ 14, 15].
41 For instance, prolonged or intense interventions for offenders at low risk of relapse, or grouping low risk offenders with those at high risk for reoffending, could result in adverse outcomes.
It was, first, a substantial act of privatisation, shifting the burden of care from the welfare state to individuals and families, whose estates would be wholly at risk in the case, for instance, of prolonged dementia.
Syphilitic involvement of the nervous system can cause cases of priapism that may be prolonged for years; most instances of the disorder last only a few hours, days, or weeks.
Unloading, for instance, during prolonged bed rest or during space flight, is known to decrease muscle cross-sectional area (CSA) (Alkner and Tesch 2004; Reeves et al. 2002; Shackelford et al. 2004) and strength (Dudley et al. 1992; Berg et al. 1991; LeBlanc and Schneider 1992; de Boer et al. 2007; Mulder et al. 2009).
In most instances, we observed prolonged incubation periods when Syrian 263K was inoculated into the new hosts.
Resistance to IT among clinicians is well known ([ 3, 10, 30, 31]), and such resistance has led in too many instances to failed, prolonged, or suboptimal implementation of new systems [ 10].
Although time-limited treatment with high-dose EPO may be beneficial and safe during acute ischemic injury, if prolonged therapy is required (for instance during heart failure), drug regimens using low-dose EPO (or EPO devoid of erythropoietic effects) may be more suitable to avoid the adverse effects of the treatment (see [38] for review).
Although time-limited treatment with high-dose EPO may be beneficial and safe during acute ischemic injury, if prolonged therapy is required (for instance during heart failure), drug regimens using low-dose EPO (or EPO devoid of erythropoietic effects) may be more suitable to avoid the adverse effects of the treatment (see [ 38] for review).
Other groups, however, are at risk as well: Men who ride motorcycles or who sit for prolonged periods of time (for instance, at sedentary jobs) are also at a higher risk of developing this problem.
