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These studies included 48, 23, and 8 patients, respectively; 10.5% of patients had prolonged increase of blood urea nitrogen levels (average increase of 50 mg/dl) [ 26], 26.1% of patients experienced renal impairment during therapy [ 27], and 50% had a fall in creatinine clearance (with a range of 16.5 to 38 ml/min) and an increase in serum creatinine levels (with a range of 0.2 to 2 mg/dl) [ 28].
The link between PGE2 and the canonical WNT pathway suggests that chronic inflammation induced by a prolonged increase of PGE2 could lead to activation of WNT signaling resulting in cell proliferation and cancer.
Corals are highly sensitive to even minuscule temperature shifts, and a prolonged increase of just 1 degree Celsius above normal for a few weeks can cause bleaching.
EdTx caused a prolonged increase of the intracellular cAMP concentration.
Our data showed that the late and prolonged increase of PIP2 was spatiotemporally linked to the elevation of the fertilization envelope (Fig. 2 and 3).
The fertilized eggs then displayed a prolonged increase of PIP2 that was accompanied by the appearance of numerous spikes in the perivitelline space during the elevation of the fertilization envelope (FE).
Similar(41)
Low peritrauma cortisol levels may fail to contain the noradrenergic stress response, leading to consequent prolonged increases in levels of norepinephrine in the brain.
Postoperative acute kidney injury requiring dialysis (AKI-D) occurs in 1 to 5% of patients after cardiac surgery with cardiopulmonary bypass (CPB) and is associated with a high mortality (30 to 60%) and prolonged increased ICU length of stay.
When administered systemically in mice, the phospholipid and phospholipid−PEG TLR7 conjugates induced prolonged increases in the levels of proinflammatory cytokines in serum, compared to the unmodified TLR7 activator.
However, exposure of these cells to damaging agents that induce prolonged substantial increase of active Ras/ERK level results in initiation of apoptosis.
These results suggest that the PA-SME of orbifloxacin for E. coli and P. aeruginosa can be meaningfully prolonged by increase of sub-MICs.
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