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Specifically, intense or prolonged impulse input from A-δ and C afferents sufficiently depolarizes the dorsal horn neurons and results in the removal of the Mg2+ block of NMDA-gated ion channels.
It must be emphasized, however, that specific abnormalities in persons with FM have not been identified that might produce the prolonged impulse input that is necessary to initiate the events underlying the development of central sensitization and/or spinal glia cell activation.
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The facets of cognition that are struck the hardest by AD include: sustained attention, prolonged concentration, inhibition of impulse and higher order capacities for deliberation, prudence and forethought.
Therefore, dantrolene can either ameliorate conduction depression by decreasing intracellular free Ca2+ concentration (to improve gap junction conductance) or further decelerate CV via prolonging APD (as impulses traveling through partially refractory tissue).
The organophosphates and the generally less toxic carbamates exert their effects by inhibiting cholinesterase, an enzyme that prevents stimulation from becoming too intense or prolonged by destroying the acetylcholine involved in the transmission of impulses in the autonomic nervous system.
Previous studies have shown that the central motor conduction time (CMCT), which is the time taken for the nerve impulses to reach the cervical spinal roots after the stimulation of the motor cortex, is prolonged in CM.
The ovations were prolonged.
Shackling for prolonged periods.
Or perhaps prolonged it.
It was prolonged.
A prolonged silence ensues.
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