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Select prolonged functions of fibroblasts leading to extensive fibrous tissue encapsulation can be detrimental to numerous implant applications, including materials designed for the bladder, vasculature, and bone.
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Addition of testicular hyaluronidase (0.4 mg/mL) to livers preserved for 24 hours in cold UW solution followed by brief exposure to Ringer's lactate both prolonged the function of the grafted livers and improved their viability (4 of 10 grafts survived, compared with 0 of 10 in the control group).
These data suggest that prolonged heart function recovery may require more permanent graft survival of transplanted cells.
Given these findings, it is reasonable to speculate that the explanation for prolonged ovarian function lies at the molecular level, in that, knocking out the bax gene leads to activation or deactivation of a genetic component of the DNA repair mechanism which enables oocytes from the Bax-deficient mice to retain the capability to efficiently repair DNA damage even during aging.
This may be a factor in prolonged poor function in some patients after this common operation.
There is evidence of prolonged poor function in patients following total hip replacement (THR).
Additionally, new treatments for erectile dysfunction - estimated to affect 20% of older males [ 24] - have prolonged sexual functioning.
This survey demonstrates that physiotherapy practice in the UK rarely includes progressive resistance exercise; and this may be a factor in prolonged poor function in some patients.
80 Moreover, in an allogeneic human islet transplant setting using the same subcutaneous device, prolonged graft function and regulated insulin secretion without the need for immunosuppressive therapy was demonstrated.
But that interest does not equate with prolonging bodily functions as long as possible.
Will concomitant realignment increase the chance of establishing stability or would staging the two procedures not only eliminate the risks associated with the combined procedure in a significant number of patients, but also prolong the function of these patients by putting off a realignment procedure with a time-and-demand-limited survival curve?
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