If anything, it prolonged the entrapment.
Some theoretical advantages associated with liposomal encapsulation include: (i) enhanced drug delivery by increased tumor entrapment (passive targeting), (ii) prolonged drug half-life and thus reduced dosing frequency, and (iii) fewer drug-related toxicities.
The researchers prepared liposomes with high entrapment efficiencies and a prolonged drug release.
The batch of optimized microspheres were found with maximum entrapment (~ 90%), minimum loss (~ 10%) and prolonged drug release for 8 h (91.25%) which may be considered as favourable criteria of controlled release dosage form.
Nanogels demonstrate excellent potential for systemic drug delivery that should have a few common features including a smaller particle size (10 200 nm), biodegradability and/or biocompatibility, prolonged half-life, high stability, higher amount of drug loading and/or entrapment, and molecules protection from immune system [ 58].
Similarly, they can also prolong catalyst lifetime by entrapment of poisons or modify activity via transfer of chemical species to and from the active phase.
Encapsulation of cyclodextrin complexed drug into carriers will increase the drug loading capacity, entrapment efficiency, prolong the existence of the drug in systemic circulation, and reduces toxicity and provides controlled, sustained, or targeted release.
In-vitro studies carried out at pH 1.2 and pH 7.4 revealed pH independent swelling and drug release from polymeric IPN, providing controlled drug release for an extended period of time with improved entrapment efficiency, thereby concluding that this polymeric blend may be a promising system for the prolonged drug delivery.
Compared to surface adsorption onto the preformed magnetic nanoparticles, ftorafur entrapment into the polymeric shell resulted in a much better drug loading and in a slower (prolonged) ftorafur release profile.
