Sentence examples for prolonged elimination from inspiring English sources

Moreover, a markedly prolonged elimination half-life of 5-FU has been observed in a patient with complete deficiency of DPD enzyme activity (Diasio et al, 1988).

The pharmacokinetics of FTY720 is characterized by linear dose-proportional exposure over a wide range of doses, only moderate interpatient variability, and a prolonged elimination half-life (t1/2 89 to 157 hours).

Several factors may alter insulin kinetics, resulting in prolonged elimination and consequently prolonged duration of action.

Older adults (65+) have a slightly prolonged elimination (approximately nine hours).

This has been attributed to the higher protein binding and prolonged elimination half-life of ibandronate.

This may have partly contributed to the prolonged elimination half-life of proguanil (Fig.  1), but not its toxicity [ 2].

Pharmacokinetic analysis suggested prolonged olanzapine elimination at elevated concentrations, attributed to the reduction in liver metabolism and renal clearance.

Starch promoted peripheral accumulation of the later infused Ringer´s acetate solution and markedly prolonged the elimination half-life.

WBH increased Ro 03-8799 plasma concentrations and prolonged its elimination t1/2 by 26% (P less than 0.01).

In a recent study, Nakada et al. have shown prolonged cytokine elimination during CRRT when using a PMMA-based hemodialyzer, but the extent of adsorption and convection clearance were not clarified [ 26].

They have a high genetic barrier to development of resistance [ 3] and when coadministered with ritonavir, resulting in increased absorption and/or prolonged terminal elimination half-life, have increasing potential for decreased dosing frequency.