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(2013) identify a surprising new "immune landscape" associated with prolonged disease-free survival.
Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors.
The difficulty in achieving prolonged disease-free survival, especially in colorectal cancer, underscores the need to investigate multimodality approaches that include local ablative techniques.
In addition to pathologic heterogeneity, there is clinical diversity within lymphomas, with some patients achieving cure, others having prolonged disease stabilization, and still others experiencing a rapidly fulminant decline and death.
This review focuses on a number of key agents that are being investigated for the treatment of HER-2-negative breast cancer and the utilization of these agents as combination therapy to achieve prolonged disease control.
Kaplan Meier life curves suggested that treatment with SUN N8075 prolonged disease onset (p = 0.012) and survival (p = 0.011) in H46 rats (Fig. 4E,F).
Kaplan Meier life curves suggested that treatment with SUN N8075 prolonged disease onset (p = 0.024) and survival (p = 0.0351) in the G93A mice (Fig. 4B,C).
For patients with progressing CLL, treatment with conventional doses of chemotherapy is not curative; selected patients treated with allogeneic stem cell transplantation achieved prolonged disease-free survival [4], [5].
In contrast, a high amount of HER4 was clearly associated with prolonged disease-free survival.
Erlotinib in combination with rapamycin produced prolonged disease stabilization in 2/19 (10.5%) low-grade glioma patients [178].
In addition, three of the total of 10 patients with renal carcinoma experienced prolonged disease stabilisation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com