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Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors.
Kaplan Meier life curves suggested that treatment with SUN N8075 prolonged disease onset (p = 0.012) and survival (p = 0.011) in H46 rats (Fig. 4E,F).
Kaplan Meier life curves suggested that treatment with SUN N8075 prolonged disease onset (p = 0.024) and survival (p = 0.0351) in the G93A mice (Fig. 4B,C).
In addition, three of the total of 10 patients with renal carcinoma experienced prolonged disease stabilisation.
Two patients had prolonged disease stabilization that lasted for 37 and 28 weeks, respectively.
Four patients were alive at 2 years and three showed prolonged disease control of 344, 525 and 550 days.
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(2013) identify a surprising new "immune landscape" associated with prolonged disease-free survival.
The difficulty in achieving prolonged disease-free survival, especially in colorectal cancer, underscores the need to investigate multimodality approaches that include local ablative techniques.
In contrast, a high amount of HER4 was clearly associated with prolonged disease-free survival.
Indeed, GIST patients treated with imatinib now experience prolonged disease-free and overall survival [13], [80], [81].
Perioperative administration of DDAVP at high doses of 1 μg/kg significantly prolonged disease-free and overall survival.
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