Obesity, and comorbid complications, are occurring at an increasingly younger age, prolonging the burden of disease and resulting in lost years of productivity, a decreased quality of life, and a growing economic burden.
This leads to additional therapy, prolonged hospital stay, burden for patients and increased costs.
That is to say, a much higher virus burden, prolonged viremic phase or the consequent immunologic reactions might be the principle mechanism of the severe complications of disease rather than viremia alone.
More than fifty percent of HIV-uninfected XDR TB patients have been successfully treated in South Korea [6], but the duration of treatment is prolonged and the financial burden is high [7].
It may be that this approach would be of particular value in those individuals with a large tumour burden needing prolonged treatment with pre-operative chemotherapy.
We show that mice with preexisting atherosclerosis randomly allocated to a sepsis group had prolonged inflammation, increased atheroma burden, and greater macrophage infiltration into atheromatous plaques than sham-operated controls.
When combined with the conventional cytotoxic, gemcitabine, in a randomised, placebo-controlled preclinical trial in KPC mice, PEGPH20 significantly increased objective response rate, decreased metastatic tumour burden, and prolonged median survival (Provenzano et al, 2012).
Intratumoral or intravenous transplantation of F3.CD human NSCs led to marked reduction in tumor burden and significantly prolonged the survival of brain tumor-bearing rats.
17 32 The combination of frequent admissions and prolonged LOS will accentuate the cost burden of COPD in deprived areas.
However, concurrent chemoradiotherapy produced more adverse events, elevated surgical risk, prolonged treatment duration, and increased financial burden compared with chemotherapy alone [14], [15].
