Sentence examples for prolonged arrest from inspiring English sources

In particular, fibroblasts were arrested in mitosis with monopolar spindles and died upon prolonged arrest.

Nevertheless, these DSBs are probably repaired eventually, perhaps due to increased activity of other repair pathways or prolonged arrest in cell cycle checkpoints allowing maintenance of fragile site stability.

Specifically, CCR4 and DHH1 behave as checkpoint adaptation genes since following IR, diploid ccr4Δ or dhh1Δ cells show prolonged arrest in G1; therefore they are required for re-entry into the cell cycle following DNA damage.

Mitotic cell death following prolonged arrest is an important death mechanism that is not completely understood.

After prolonged arrest in mitosis, cells appeared to adapt to the absence of a mitotic spindle and escaped from mitosis.

Moreover, as the replication licensing inhibitor geminin accumulates during prolonged arrest, re-licensing of replication origins will be blocked.

The results of the present study indicate that in prolonged arrests bicarbonate therapy and a period of perfusion prior to defibrillation may increase survival.

The preferred mode of DNA translocation for sequencing applications is stepwise displacement, whereby prolonged arrests of DNA motion, required for sufficient signal-to-noise identification of the nucleotide, alternate with rapid, ideally single nucleotide or base pair displacements of the molecule.

Thus, reducing the threshold for MOMP using BH3 mimetics achieves the same goal as prolonging arrest in mitosis.

However, APC/C is not only a major effector of the SAC that ensures cell cycle arrest upon spindle disruption but it also promotes cell death upon prolonged mitotic arrest [ 10].

Such DDR-positive telomeres, and those that occur as part of the telomere-dependent prolonged mitotic arrest checkpoint, normally pass through mitosis without covalent ligation, but result in cell growth arrest in G1 phase.