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In summation, prolonged applications of high dose Aβ42 are likely neurotoxic.
Morphine-induced hyperalgesia is a pharmacological phenomenon often hindering its prolonged applications in the clinic.
Currently, electrical stimulation and/or brief applications of high K+ are considered to be the most appropriate CSD-inducing stimuli, rather than prolonged applications of high K+, for the better understanding of "spontaneous" CSD mechanisms occurring in migraine aura [62].
The knowledge gained herein provides a better understanding of the material degradation and wear mechanism associated with ageing, and is useful for designing and selecting proper operation conditions for prolonged applications of the material under extreme circumstances.
For this purpose, currents evoked by prolonged applications of saturating [GABA] were studied.
For dental professionals, obvious measures to prevent the risk of tooth sensitivity is to avoid multiple in-office bleaching sessions with prolonged applications of high-concentrated hydrogen peroxide and to make gap-free fillings.
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Precautions are taken in the case of open wounds, hypertension, poor sensation, aversion to cold, poor mentation, prolonged application over a superficial nerve, and patients who are very young or very old.
However, prolonged application of high dose Aβ42 resulted in network activation and tonic firing.
Taken together, our data suggest that prolonged application of high fluid shear to human T/C-28a2 chondrocytes recapitulates the earmarks of OA, and illustrate a link between high mechanical forces and the development of OA.
We thus evaluated whether prolonged application of high fluid shear to human T/C-28a2 chondrocytes modulates the expression of key marker genes of OA in a manner similar to that detected in OA relative to healthy chondrocytes.
Another interesting aspect was the observation, that prolonged application of antibiotics was found in the LAG.
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