Since these cells have a growth advantage, prolonged culturing of the A2780 cell line can result in selection of this subpopulation.
Owing to their advantages (prolonged residence time, providing long periods of therapeutic drug levels at disease sites, and good stability of active ingredients), mucoadhesive films or patches represent the most recently developed medical formulation for oral application.
In animal models, monotherapy nanomedicines successfully take advantage of prolonged blood circulation times to efficiently deliver therapeutic agents to tumors via the enhanced permeability and retention (EPR) effect.
Irreversible kinase inhibitors have a number of potential advantages including prolonged pharmacodynamics, suitability for rational design, high potency, and ability to validate pharmacological specificity through mutation of the reactive cysteine residue.
This formulation was designed to overcome vehicle toxicity associated with the traditional Cremophor EL-based formulation and to provide the added advantages of prolonged systemic circulation time and selective targeting of the FR, which is frequently overexpressed on epithelial cancer cells.
As a matter of facts, the cell-based delivery system possesses a number of advantages including prolonged delivery times, targeting of drugs to specialized cell compartments and biocompatibility.
The potential financial damage was seen as limited at least initially for Deutsche Telekom, which owns the largest fixed-line and mobile businesses in Germany and routinely appeals adverse legal decisions in German and European courts to prolong its commercial advantage over rivals, rivals said.
The danger that some at home or abroad could try to prolong and take advantage of instability.
In another 'stratagem', Polyaenus suggests that Philip deliberately prolonged the battle, to take advantage of the rawness of the Athenian troops (his own veterans being more used to fatigue) and delayed his main attack until the Athenians were exhausted.
