Sentence examples for prolonged administration from inspiring English sources

Unfortunately, the only drugs now available for Chagas' disease, Nifurtimox and Benznidazole, are relatively toxic for adult patients, and require prolonged administration.

These findings suggest that prolonged administration of cannabinoid receptor agonists could be an appropriate strategy for selectively improving motor symptoms and stimulating neuroprotective processes in HD patients.

In our study, prolonged administration of high-dose vasopressor conversely indicated an uncontrolled circulatory failure regardless of etiology (vasoplegia, myocardial depression, hypovolemia) and was associated with poor outcome.

However, upon prolonged administration, pCA gave rise to currents that lasted longer.

Therefore, 100 mg/day appears a reasonable dose for chemopreventive purposes implying prolonged administration.

The stable pharmacokinetic profile of tazarotene is a major advantage in cancer patients, where schedules often involve prolonged administration.

First, enteral administration of silibinin was well tolerated, with no adverse effect noted following prolonged administration to nontumor-bearing mice.

Subsequent studies should evaluate whether prolonged administration of these formulations results in more marked, clinically meaningful differences.

These symptoms are described in humans after the intravenous injection of tramadol and are related to prolonged administration.

In addition, prolonged administration of heparins at high doses may result in osteoporosis in animal models (Shaughnessy et al, 1995).

Thus prolonged administration of these plants may expand pancreatic β-cell mass, leading to increased insulin secretion and improved glycemic control.