Sentence examples for prolongation should be from inspiring English sources

In the absence of any completely reliable surrogate measure for the arrhythmogenic potential of a drug, regulators have determined that QT interval prolongation should be intensively investigated in every drug that is developed.

If however this recommendation were to be followed, the current positive predictive value of DDI alerts on QT prolongation should be doubled.

As torsadogenicity can be associated with prolongation of the QT interval, it has been concluded that any block of IKr or QT prolongation should be taken as an indication of pro-arrhythmic risk.

Sixty-three percent of the panel recommended that in patients with metastatic CRPC progressing by PSA without evidence of radiographic progression and in the absence of symptoms and imminent complications, agents with potential for survival prolongation should be initiated within 4 8 weeks.

Thus, metoclopramide may be associated with QTc prolongation and should be used with caution only [ 38].

With regard to QT prolongation, it should be defined what has to be done so that a combined "totality of evidence" approach to QT assessment can be applied and accepted for delay or as a replacement of a TQT study (e.g., precompetitive sharing of data, combination with other initiatives).

Possible advantages due to limited prolongation of pregnancy should be carefully weighed against the increased risks for maternal and foetal complications (abruptio placentae, acute renal failure, pulmonary oedema, DIC, perinatal and maternal death) [ 10].

16, 68 While there have not been studies evaluating this interaction, medications that prolong the QTc interval should be used with caution because there is a risk of QTc prolongation with rilpivirine at higher doses.

In order to minimize the risk it is clear that the prolongation in vitro culturing to blastocyst stage should be very well optimized.

The true purpose of CE should be to abrogate any prolongation of death, remove the discomfort arising from endotracheal intubation, and provide complete expert symptom control until death.

In fact, treatment prolongation should have been based on the control of residual disease associated with improved survival.