Sentence examples for prolongation risk from inspiring English sources

Regulatory and competitive pressure to reduce the QT interval prolongation risk of potential new drugs has led to focus on methods to test for inhibition of the human ether-a-go-go-related gene (hERG -encoded K+ chERG -encodedrimary molecular target underlying this safety issue.

One important question was how M&S can be used to improve the approach to QT prolongation risk.

In addition, a sizeable number of compounds still fail the expensive human 'thorough Qtrialias, as their QT prolongation risk remains undetected until that late stage (Gintant, 2011).

Amongst the atypical antipsychotics, ziprasidone, which is metabolized by CYP 3A4, is associated with an increased QTc prolongation risk amongst novel antipsychotics [ 75].

The key message is that evaluation of new drugs in non-rodent animal cardiovascular models can be used to predict human QT interval prolongation risk.

Telaprevir and boceprevir may interact with antipsychotics prone to corrected QT (QTc) interval prolongation and elevations in plasma levels could increase QTc prolongation risk.

In particular, the administration of clozapine, known to be associated with higher QT-prolongation risk than risperidone, had no effect on QT-length.

This qualitative relationship between QT prolongation and risk of Torsades de Pointes is treated as a surrogate of proarrhythmic risk of drugs, and therefore the ICH E14 recommends "testing the effects of new agents on the QT interval as well as the collection of cardiovascular adverse events".

43 Less common forms of LQTS have also been described, with heterogeneous molecular etiologies expressed as QT prolongation and risk of lethal ventricular arrhythmias.

Although prolongation of risk is most pronounced after hospitalization for heart failure, patients admitted with any of the three conditions are at considerably higher risk of adverse outcomes than the general elderly population for the full year after hospital discharge.

The single most important concern with drug-induced QT prolongation is risk of fatal polymorphic ventricular tachycardia, or torsades de pointes (characterized by QRS complexes of progressively changing amplitude and contour that seem to twist around the isoelectric line from beat to beat).