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In this study, we have shown that abrogation of dNTP biosynthesis, which is caused by csn1Δ, ddb1Δ or cdc22-M45 mutatiors or HU treatment, markedly prolongs the duration of horsetail nuclear movements and that this prolongation results from activation of the Cds1-dependent DNA replication checkpoint.
APD prolongation results in delayed repolarization times and QT prolongation but by a smaller amount (by 5.7%and11%1% respectively).
The absence of T2 prolongation results from the dense cellularity and high nucleus-to-cytoplasm ratio of lymphoma, and it may help in the differentiation of primary CNS lymphoma from other brain tumours [ 1- 3].
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These data are consistent with the idea that TETA-mediated prevention of QTc prolongation resulted from normalization of myocardial copper regulation, pointing to the existence of copper-mediated mechanisms that contribute to QTc regulation.
Serious adverse events (SAE's) are those events that result in death or are life threatening, result in hospitalization or prolongation of hospitalization, result in persistent or significant disability, or result in a congenital birth defect.
Serious TEAEs (defined as those that resulted in death, were life threatening, required hospitalization or prolongation of hospitalization, resulted in persistent or significant disability or incapacity, caused congenital abnormality or birth defect, or were considered an important medical event) were reported in two studies.
However, it is increasingly clear that compound-induced interactions with multiple cardiac ion channels may significantly affect QT prolongation that would result from inhibition of only IKr [Redfern, W.S., Carlsson, L., et al., 2003.
This is not only because positively charged NPs more effectively penetrate through the membrane, but also because they are more strongly bound to the negatively charged DNA, causing its damage and, as a result, prolongation of the G0/G1 phase of the cell cycle.
Reduced arrhythmogenesis is attributable to prolongation of ERP resulting from improved intercellular coupling via increased expression of connexin43, and attenuation of unfavorable remodeling.
The CFA-induced prolongation of diestrus resulted in unequal representation of the estrous phases within our study.
Delayed detection of schizophrenia and the resulting prolongation of the duration of untreated psychosis (DUP) are viewed as serious issues in the mental health field [ 1- 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com