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Since regular ECG monitoring was performed, it was expected that a higher QT prolongation rate would be found.
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The most common endpoint of drug screening system in mice is prolongation of survival rate but not the cure rate, when compared with control group receiving no drugs, in which all mice in test group would eventually die.
Besides, the efficacy of acupoint stimulation on the prolongation of survival rate for lung cancer patients remains unexplored.
Previous studies of other twice-daily LABAs in both patients and healthy volunteers have shown that they can be associated with β2-mediated systemic adverse effects such as headache, palpitations with changes in heart rate, prolongation of the QTc interval and increased glucose and/or decreased potassium blood levels.
Transient prolongation of heart rate-corrected cardiac QT interval (QTc) was seen at high doses (⩾2000 mg m−2).
Diverse cardiac and non-cardiac drugs are associated with prolongation of the rate-corrected QT (QTc) interval of the electrocardiogram and with a risk of the potentially fatal arrhythmia Torsade de Pointes (TdP) [1 4].
The observed prolongation of the heart rate corrected QT interval (QTc) during hypoglycaemia varies greatly between studies.
Most preclinical trials are designed to identify potential torsadogenicity test only for surrogates of torsade de pointes, most commonly prolongation of the heart rate corrected QT interval (QTc).
Cardiac adverse events, particularly the increase of heart rate and prolongation of the QT interval associated with polymorphic ventricular tachycardia (or torsade de pointes), can be serious, and the antimuscarinic agent terodiline was withdrawn from the market because of an association with QT prolongation [103].
Regardless of endoscopists' experience, we demonstrated that poor bowel preparation resulted in a reduced cecal intubation rate and prolongation of colonoscopy time.
The protective effect of the experimental anti-viral drugs was evaluated according to the rise of the survival rate and prolongation of mean life of the experimental animals as compared with the control animals.
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CEO of Professional Science Editing for Scientists @ prosciediting.com