Moreover, not only was the amplitude of the instantaneous response (first or second time bin) less than expected, but there was not a clear prolongation of the response.
In agreement with the electrophysiological recordings of GIRK channel activity, BRET experiments showed that the increase in Gβγ stoichiometry over an effector results in prolongation of the response deactivation lag.
This effect is most parsimoniously explained by the additional activation of a receptor "reserve" [46], [47], although the major effect of benzodiazepines may be due to the prolongation of postsynaptic responses [48].
The pretension of the external wrapping achieved in this study, resulted in the prolongation of the elastic response of the column by 40% in terms of load.
In a close vicinity to a state change or tipping point, dynamical systems exhibit increased susceptibility and fragility, which manifests as amplification and prolongation of the system response to intrinsic or experimentally induced perturbations [1].
Escalation and prolongation of the inflammatory response at D7 post-MI in the MMP-9i group was evident by increased expression of 18 pro-inflammatory cytokines (all p < 0.05).
This agent was also developed as a maintenance therapy with a significant prolongation of the therapeutic response.
Patients who exhibited a complicated clinical trajectory, defined as greater than fourteen days of persistent organ dysfunction or death, had exacerbation and prolongation of their transcriptomic response, and failure to return to baseline expression patterns [ 6].
On the other hand, response may be somewhat less reliable with immunotherapeutic approaches since in some instances, there may be delayed tumor shrinkage, with or without a period of continued tumor growth prior to onset of sustained tumor shrinkage [ 82, 123], or there may be prolongation of survival without response or improvement in PFS [ 124].
In some measurements where microiontophoretical application of BIC was performed (cf. below), stimuli were presented with 500 ms duration (cf. Fig. 4), as sometimes prolongations of neuronal responses have been reported during BIC-application (e.g. Refs. [13] [16], [23]).
