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In contrast, continuous infusions of the other 4-anilidopiperidine opioids result in accumulation and considerable prolongation of effect with increased duration of infusion [ 10], making these opioids intermediate-acting or long-acting agents during prolonged infusion.
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Too often her dances began with bright ideas that gradually dimmed with repetition or prolongation of effects.
Without proper discontinuation and/or continued use, perioperative concerns include perioperative bleeding, cardiac side effects (hypertension, hypotension, tachycardia, angina), water/electrolyte disturbances, hypoglycemia, and prolongation of anesthetic effects (Table 3).
The observed reduction in the absorption rate of bupivacaine into the systemic circulation for both viscous hyaluronic formulations after 6 mg of bupivacaine may explain the prolongation of spinal effects.
The rapidly recovering cells were sensitive to COX-2 inhibition, which caused a prolongation of the endocannabinoid effect.
This binding of both macrolactones distinguishes quinupristin/dalfopristin from other antibiotic classes (66, 67 ), with the attendant prolongation of the postantibiotic effect (68 ) representing a distinct advantage over older agents (69 ).
We have shown in murine models of a number of common malignancies that there is a significant repression of hepatic Cyp3a11 mRNA expression in tumour-bearing mice compared with controls, functionally reflected by a prolongation of the sedative effect of midazolam, a CYP3A substrate.
Although β1-antagonism produced a partial reduction in APD30 prolongation, the effect of noradrenaline was completely abolished with combined β1-/β2-blockade using either 100 nM ICI-118,551 in combination with 10 µM atenolol or 1 µM propranolol.
A possible explanation for the prolongation pharmacological effect of P MVEMA) nanoparticles is that the nanoparticles dispersion was more viscous than the sCT solution even compared at the same concentration.
Objective: To assess the effect of prolongation of pregnancy on neonatal outcome by means of hemodynamic treatment in patients with early-onset preeclampsia.
The previously mentioned study by Bernstein et al. that evaluated Co-fact© (a nonactivated PCC) for the reversal of anticoagulation showed that rivaroxaban effect (prolongation of PT) was immediately and completely reversed by PCC (PT came back to normal) [ 26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com