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Although flupirtine left aIPSC peak amplitudes unaltered, the drug caused a prolongation of current decay.
Therefore as far as increasing of prolongation of current of RA, specific gravity of patients with anemia increases.
Serious adverse events were defined as events resulting in persistent or significant disability or incapacity, new hospitalization or prolongation of current hospitalization, severe hypoglycemia, and life-threatening events or death.
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(Serious adverse medical events include conditions resulting in hospitalization for >24 hours, prolongation of a current hospitalization, permanent or severe disability, death, or congenital abnormality in pregnancy; are life threatening; or are involved in an accidental or intentional medication overdose).
Prolongation of whole-cell Na+ currents has been observed in a variety of cultured nervous system tissues exposed to pyrethroids [ 8- 10].
It was also demonstrated that soluble and membrane-bound antigens can greatly enhance antibody clearance via antigen-mediated elimination mechanisms [27], [31], prompting the speculation that in the current study, prolongation of anti-PA antibody residence in the bloodstream may confer improved protection.
Block of the fast sodium current causes prolongation of the QRS interval, a known cardiac risk marker, especially for class 1C anti-arrhythmic drugs.
49 This current contributes to prolongation of the plateau phase within the cardiac action potential, effectively prolonging repolarization and accounting for the resultant long QT interval.
Indeed, it has been recently reported that AMPK activation may induce an enhancement of L-type calcium current I Ca) and a prolongation of the action potential duration in cardiomyocytes [ 47].
Prolongation of repolarization through reductions in repolarizing K+ currents has been speculated to induce EADs through Ca2+ channel reactivation (Haverkamp et al. 2000).
Therefore, when G f is large and E f is more depolarized, the late component of the gap junctional current is mainly an inward current for the cardiomyocyte resulting in the prolongation of its APD.
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