Sentence examples for prolongation might be from inspiring English sources
When a control sputum smear is positive at the end of the intensive treatment phase, treatment prolongation might be warranted.
Patients' and relatives' focus on life prolongation might be a reason for the fact that perceptions regarding euthanasia and views on withdrawing or withholding treatments were only investigated in studies among professionals.
For example, if clinicians tended to prescribe sertraline to patients who had experienced myocardial infarction on the basis of the SADHART or SADHART-CHF trials, 29 30 a spurious association between sertraline and QT prolongation might be observed.
With more knowledge on the genetic variation associated with drug-induced QT interval prolongation, we might be able to identify which patients would benefit, and which patients would be at risk, and subsequently not have to withdraw drugs with QT-prolonging properties from the market completely [ 101].
Then, we considered that further prolongation of survival might be obtained by improvement of local control, adding concurrent thoracic irradiation to induction chemotherapy.
Although the overall survival (OS) of patients with ATL has increased marginally because of advances in chemotherapy, further prolongation of survival might be difficult with conventional chemotherapy alone.
Given that CVD is a broad set of diseases and condition, QTc prolongation might not be a main driver of the overall CVD mortality.
The risk allele is defined as the allele that increases the risk of QT interval prolongation, and hence it might be different from the coded allele (for example, the risk allele of rs12053903 in SCN5A is T and not the coded allele C; Table 1).
The outcome of this is a prolongation of the travelling time that might be unacceptable.
This might be helpful in prolongation of drug release, increased absorption, bioavailability enhancement, and reducing the frequency of administration of the drug.
Since increased activity of the enzyme or a higher alpha-GPDH/6PGDH ratio are associated with a lower risk of recurrence (Deshpande et al., 1981), it is postulated that the beneficial effects of tamoxifen or prednisolone in terms of prolongation of the relapse free interval might be mediated via alterations in the activity of alpha-GPDH in micrometastases.
