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As grams expressing Prolongation can always express Increment, we combine the notion Prolongation into Increment.
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Once those mysteries are solved, and the crisis is over, any prolongation turns into soap opera.
In light of well publicised withdrawals of compounds from the US market, 1 drugs with high risk of QT prolongation in such assays may simply not be progressed into human trials.
However, newer data generated by randomized trials and new, larger database analyses definitely indicate that elderly patients with AML treated with aggressive therapy can achieve durable remissions, and that this translates into prolongation of survival and good quality of life.
The prolongation of the β hairpin 274 279 causes a further extension into the bulk solvent and a rotation by approximately 10° towards the DI side of the hinge (Fig. 1B d and e).
The memos emphasized a potential risk called QT prolongation, in which the heart delays recharging electrically.
hERG channel blockers delay repolarization, which prolongs the action potential duration (APD), and this translates into a prolongation of the QT interval.
Until very recently, most of the increase has been due to better survival in childhood and youth, rather than the increased prolongation of middle age into old age.
This first image, therefore, implies that duration is memory: the prolongation of the past into the present.
Initially focused on the issue of drug-induced QT prolongation it has developed into an important discipline over the past 15 years with expertise beyond its initial focus on torsades de pointes (TdP).
Whether slowing down tumour progression would translate into survival prolongation and/or quality of life improvement remains to be determined.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com