Sentence examples for prolongation has been from inspiring English sources

In these studies a prolonged weaning-to-service interval was recorded at the high temperatures; this prolongation has been reported to associate partly with a reduced appetite [ 33, 35].

Concentration-dependent QT prolongation has been demonstrated in vitro with such recent drugs as risperidone on Purkinje fibers and in isolated feline hearts.

Beyond the common challenges in drug design related to ADME and safety profiles, cardiovascular risk involving hERG binding and the potential for subsequent drug-induced QTc prolongation has been a major hurdle for a significant number of MCH-R1 research programs.

QTc prolongation has been a concern with nilotinib and dasatinib.

81 Cardiac toxicity, namely QT prolongation, has been reported with nilotinib.

No significant QT prolongation has been observed in patients taking ecallantide.

Although small clinical trials with IV and PO granisetron 18– 23 have not found any significant changes in QT intervals, individual reports of QT prolongation have been published.

In a prior study, users of metoclopramide did not show an increase in risk of ventricular arrhythmia compared with users of PPIs [ 22], but spontaneous events of QT prolongation have been reported with metoclopramide exposure, mainly via the intravenous route and in critically ill subjects [ 23– 28].

10, 91 QT-Prolongation has been a concern since there have been reports of possible QT prolongation 19, 24 and one case of atrioventricular block after sugammadex.

Electrocardiogram (ECG) changes, including ST-segment and T-wave changes and corrected QT (QTc -prolongations, have been described with various HDAC inhibitors 9– 20 and a class effect has been suggested 9, 10, 18.

Potassium current (or hERG) block results in prolongation of the QT interval due to APD prolongation, which has been related to increased risk of Torsades de Pointes.