Sentence examples for prolongation effect from inspiring English sources

Case reports of patients with other types of leukodystrophy have shown that rocuronium, vecuronium, and atracurium can be safely used without a prolongation effect [8 10].

We did not administer any muscle relaxants for any of our patient's three operations because of the risks of hyperkalemia following succinylcholine in patients with neuromuscular disease and the prolongation effect following the administration of non-depolarizing agents.

At higher doses, the QTc prolongation effect is more pronounced and patients who are overdosed with rilpivirine should have electrocardiographic monitoring performed.

The QT/QTc prolongation effect of TV-1106 was limited to the highest dose (100 mg) tested in TV-1106-SAD-102 study, and was not supported by the PK/PD analysis.

The prolongation effect was initiated within 2 min after GLP-1 perfusion and reached the maximal level around 10 min. The GLP-1-induced APD prolongation was recoverable after washing out of the compound (Fig. 4A and Table 1).

Consistent with the known QTc prolongation effects of moxifloxacin, the lower bound of the two-sided 90% adjusted CI of ΔΔQTcP for moxifloxacin was >5 ms at two of the three prespecified time points, confirming assay sensitivity.

Our simulation results also show that when IKr block is added to ICaL block, QT shortening still occurs but becomes milder due to the APD90 prolongation effects of IKr block.

A panel of drugs with known QT-prolongation effects, including erythromycin, sotalol and cisapride, and a non-drug compound, E-4031, were investigated.

There are some data to suggest that there may be inter-ethnic differences in drug-induced QT-prolongation effects [ 45], and that risk of QT interval prolongation may be increased in females, patients with organic heart diseases and patients with hypokalaemia [ 46], but further investigation of these factors is required.

In contrast, continuous infusions of the other 4-anilidopiperidine opioids result in accumulation and considerable prolongation of effect with increased duration of infusion [ 10], making these opioids intermediate-acting or long-acting agents during prolonged infusion.

QTc prolongation can effect from the inhibition of human ether-a-go-go related gene (hERG) channel, which is responsible for the rapid component (IKr) of the delayed-rectifier potassium current, involved in the cardiomyocytes membrane repolarization.