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The neutron fluence load on a reactor pressure vessel is an important physical quantity affecting material degradation and consequently reliable assessment of pressure vessel integrity and lifetime prolongation beyond designed conditions.
Pregnancy prolongation beyond 38 weeks increases the risk to develop fetal macrosomia, without reducing C-section rate.
PT and aPTT are poor predictors of clinical bleeding unless a marked prolongation (that is, prolongation beyond the limit of machine measurements) is observed [ 30].
Moreover, EVE + EXE could offer an additional first-line treatment option, providing PFS prolongation beyond the duration that would be expected with endocrine therapy alone, which is currently the recommended standard of care in this patient population [ 4, 5].
The risk-benefit ratio is quite favorable at the start of treatment in patients with a good indication, but prolongation beyond 5 years might not further reduce the absolute risk of ordinary fractures, as concluded by the U.S. Food and Drug Administration (Whitaker et al. 2012)—a conclusion that has been partly contested by some researchers in the field (Black et al. 2012).
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Participants receiving dronedarone had less reduction in heart rate, had fewer QTc prolongations beyond 500 ms, and had fewer elevated international normalized ratio (INR) compared with those on amiodarone.
There was no significant effect post AED therapy on the normal QTc group (Fig. 6C), but for 20.3% (11 of 54) the QTc was prolonged beyond the threshold for QTc prolongation after treatment (Fig. 6D).
Despite significant improvements in recent years, the treatment of metastatic colorectal cancer (mCRC) for the vast majority of patients is rarely curative, and thus the aims of treatment in this setting extend beyond prolongation of survival to include the improvement of tumour-related symptoms, prevention of tumour progression and/or maintenance of quality of life (Van Cutsem et al, 2010).
The tail in vertebrates is a prolongation of the body beyond the anus.
Tail, in zoology, prolongation of the backbone beyond the trunk of the body, or any slender projection resembling such a structure.
Prolongation of the study beyond 36 weeks may potentially have resulted in a sustained increase in the incidence of proteinuria in control compared with treated mice.
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