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MEA recordings showed dose-dependent QT interval prolongation after treatment with repolarization-prolonging anti-arrhythmic drugs.
All stages of interphase were prolonged, in contrast to the interphase prolongation after treatment with high concentrations of the mitotic inhibitors vincristine and vinblastine, which occurs in G2.
There was no significant effect post AED therapy on the normal QTc group (Fig. 6C), but for 20.3% (11 of 54) the QTc was prolonged beyond the threshold for QTc prolongation after treatment (Fig. 6D).
QTc prolongation after Bazet and Fridericia corrections were not present after the single-dose administration.
It has been postulated that the survival prolongation after palliative resection may be partially due to tumor-debulking surgery [ 21].
The mechanism of QT prolongation after macrolides is blockage of the outward potassium current or channel in myocyte membranes [ 32].
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Logistic regression analysis showed that the frequency of severe hypoglycemia was independently associated with QTc prolongation, even after adjustment for diabetes complications, including autonomic neuropathy (odds ratio 1.27, 95% CI 1.02 1.58).
Open image in new window Fig. 1 Sleep stages from total sleep time (TST) in a Gullian Barré Patient early after hospital admission (left) with marked prolongation of waking after sleep onset (W) and shortening of each N2% and REM% of TST.
ischiadicus) as the prime pathway for CNS invasion of the scrapie agent after footpad-infection, as evidenced by a substantial prolongation of survival after neurectomy (Kratzel et al., submitted for publication).
In conclusion, oral maintenance tocolysis has no significant impact on further prolongation of pregnancy after intravenous tocolysis.
One other possible strategy for behavioral adjustment has been described in previous experiments on humans by Rabbitt et al. [29], who reported a prolongation of RT after an erroneous response that seemed to be more evident in reaction time tasks.
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CEO of Professional Science Editing for Scientists @ prosciediting.com